Mouse Anti-Human CD279

Mouse Anti-Human CD279 (0.1 mg)

DS-MB-02967
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Antigen Information

Protein Name & Synonyms:
CD279
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, Flow Cytometry
Concentration:
IgG concentration 1.0mg/ml
Species Reactivity:
Human

Specificity

This product detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1). CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation.

Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Human CD279 - transfected L cells.
Preservative:
0.09%Sodium Azide (NaN3)
This product
Spleen cells from immunised C3H mice were fused with cells of the P3U1 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.