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Antigen Information

Protein Name & Synonyms:

CD284

Target Species:

Human

Antibody Specifications

Applications:

Flow Cytometry, Functional Assays, Immunoprecipitation, Western Blotting

Concentration:

IgG concentration 1.0 mg/ml

Species Reactivity:

Human, Rhesus monkey

Specificity

This product recognizes the human Toll like receptor 4 (TLR4) cell surface antigen.

TLR4, also known as CD284, has been demonstrated to act as a receptor for LPS on human monocytes and macrophages. TLR4 signalling of LPS stimulation requires the presence of the MD-2 molecule.

TLR4 is weakly expressed by resting cells, but is upregulated following stimulation with LPS.

This antibody has been demonstrated to block activation of monocytes with LPS.

Storage/Stability

Store at -20 °C only.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:

Purified IgG - liquid

Formulation:

Phosphate buffered saline

Quality Control (Contaminants):

<0.01 EU/ug

Format Type:

Low Endotoxin

Preparation

Immunogen:

Ba/F3 cell line expressing TLR4 (CD284).

Preservative:

None present

This product