Mouse Anti-Human CD284

Mouse Anti-Human CD284 (0.5 mg)
CODE:  DS-MB-00578

Antigen Information

Protein Name & Synonyms:
CD284
Target Species:
  • Human

Antibody Specifications

Applications:
Flow Cytometry, Functional Assays, Immunoprecipitation, Western Blotting
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Human, Rhesus monkey

Specificity

This product recognizes the human Toll like receptor 4 (TLR4) cell surface antigen.

TLR4, also known as CD284, has been demonstrated to act as a receptor for LPS on human monocytes and macrophages. TLR4 signalling of LPS stimulation requires the presence of the MD-2 molecule.

TLR4 is weakly expressed by resting cells, but is upregulated following stimulation with LPS.

This antibody has been demonstrated to block activation of monocytes with LPS.

Storage/Stability

Store at -20 °C only.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Quality Control (Contaminants):
<0.01 EU/ug
Format Type:
Low Endotoxin

Preparation

Immunogen:
Ba/F3 cell line expressing TLR4 (CD284).
Preservative:
None present
This product
Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line.