Protein Name & Synonyms:
Human, This antibody is reported to cross react with Cynomolgus monkey and bovine
This product recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes.
CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains.
The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
Store at +4 °C.
DO NOT FREEZE.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.
Purified IgG conjugated to R. Phycoerythrin (RPE) - liquid.
Phosphate buffered saline
PHA stimulated lymphoblasts.
|1%||Bovine Serum Albumin|
Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.