Mouse Anti-Human CDw328 [+FITC]

Mouse Anti-Human CDw328 [+FITC] (0.1 mg)
CODE:  DS-MB-03269

Antigen Information

Protein Name & Synonyms:
CDw328
Target Species:
  • Human

Antibody Specifications

Applications:
Flow Cytometry
Concentration:
IgG concentration 0.1mg/ml
Species Reactivity:
Human

Specificity

This product is specific for human CDw328, a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase.

CDw328 is expressed predominantly by natural killer cells (NK) and to a lesser extent by monocytes and granulocytes and, like Siglec-5 (CD170), has been shown to bind to sialylated ligands of targets through recognition of sialic acid in both the alpha-2,3- and alpha-2,6- glycosidic linkage.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
Formulation:
Phosphate buffered saline

Preparation

Immunogen:
Monocyte-derived dendritic cells
Preservative:
0.09%Sodium Azide (NaN3)
1%Bovine Serum Albumin
This product
Spleen cells from immunised Balb/c mice were fused with cells of the X63-Ag8.653 myeloma cell line.