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Antigen Information
Accession Number:
- Q16619
Antigen Catalog Number:
230-00008
Protein Name & Synonyms:
CT1
Target Species:
- Human
Antibody Specifications
Host Species:
Mouse
Species Reactivity:
Human, The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. The mouse anti-human CT-1 antibody binds to the target derived from human recombinant protein at various concentrations. Cross reactivity with mouse and rat was not tested.
Clonality:
Monoclonal
Isotype:
Igg
Specificity
The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. The mouse anti-human CT-1 antibody binds to the target derived from human recombinant protein at various concentrations. Cross reactivity with mouse and rat was not tested.
Storage/Stability
Store at 4°C if intended for use within one month, otherwise, store at -20 °C to -80 °C. The lyophilizedantibody is stable for at least 18 months after the date of receipt when stored at -20 °C to -80 °C. Afterreconstitution, it can be aliquoted and stored frozen at -20 °C to -80 °C in a manual defrost freezer for 6months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1month at 4 °C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.
Format
Powder obtained from lyophilization
More Information
Target Description
Cardiotrophin-1 (CT-1; Official gene name: CTF1) is a cardiac hypertrophic factor and belongs to the IL-6 cytokine family. The protein interacts with the glycoprotein 130/leukemia inhibitory factor receptor beta heterodimer. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice. In addition, CT-1 enhances transcription factor NF kappa B DNA-binding activities and activates phosphatidylinositol 3-kinase in cardiac myocytes. It is also highly expressed in the heart, prostate, skeletal muscle, and ovary, and expressed at the lower levels in lung, kidney, pancreas, thymus, small intestine, and testis. CT-1 is highly secreted by myotubes, and promotes the survival of cultured embryonic mouse and rat MNs. CT-1 is associated with pathophysiology of heart diseases, like hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.
Immunogen
Mouse Anti-Human CT-1 Antibody
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
