Protein Name & Synonyms:
Flow Cytometry, Functional Assays
This product recognizes human Dectin-1, also known as beta-glucan receptor (Î²GR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells.
Human Dectin-1 has two major (Î²GR-A and Î²GR-B) and several minor isoforms. Î²GR-A and Î²GR-B differs by the presence and absence, respectively, of a stalk region. This antibody recognizes both of these isoforms. This product could be used to inhibit receptor function.
Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Quality Control (Contaminants):
NIH3T3 cells expressing full length Beta-glucan receptor.
Spleen cells from immunised C57BL/6 mice were fused with cells of the murine SP2 myeloma cell line.