Mouse Anti-Human Dectin-1, Low Endotoxin

Mouse Anti-Human Dectin-1, Low Endotoxin

129-10237
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Antigen Information

Protein Name & Synonyms:
Dectin-1
Target Species:
  • Human

Antibody Specifications

Applications:
Flow Cytometry, Functional Assays
Concentration:
1.0mg/ml
Host Species:
Mouse
Species Reactivity:
Human

Specificity

This product recognizes human Dectin-1, also known as beta-glucan receptor (βGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells.

Human Dectin-1 has two major (βGR-A and βGR-B) and several minor isoforms. βGR-A and βGR-B differs by the presence and absence, respectively, of a stalk region. This antibody recognizes both of these isoforms. This product could be used to inhibit receptor function.

Storage/Stability

Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Quality Control (Contaminants):
<0.01EU/ug
Format Type:
Low Endotoxin

Preparation

Immunogen:
NIH3T3 cells expressing full length Beta-glucan receptor.
Preservative:
None present
This product
Spleen cells from immunised C57BL/6 mice were fused with cells of the murine SP2 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.