Protein Name & Synonyms:
May be used in immunohistochemistry for staining EGFR.
0.1 mg/ml (OD280 nm)
Recognizes the (Mr 170 kDa) extracellular domain of the epidermal growth factor receptor on many cell surfaces. The EGFR mediates the initial response of cells to EGF. It has an extracellular region, which binds EGF and an intracellular region, which exhibits tyrosine kinase activity (1). The receptor phosphorylates a number of protein substrates in addition to mediating autophosphorylation of tyrosine residues located near its carboxyl terminus (2 ,3).
Store at 2-8°C. DO NOT FREEZE!
Human Epidermoid Carcinoma Line A431
Protein A Chromatography
0.01 M PBS, pH 7.4 containing 150 mM Sodium Chloride and 1% BSA.
0.09% Sodium Azide