Mouse Anti-Human Factor VIII

Mouse Anti-Human Factor VIII (0.5 mg)

129-10692
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Antigen Information

Target Species:
  • Human

Antibody Specifications

Applications:
ELISA, Western Blotting (1/100 suggested dilution), Radioimmunoassays
Concentration:
1.0 mg/ml
Host Species:
Mouse
Species Reactivity:
Human

Synonyms

F8C

Specificity

129-10692 recognizes human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross?links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream.
Defects in Factor VIII cause haemophilia A, a disorder characterised by the body?s inability to control blood clotting. This could result in severe blood loss, even with minor injuries. 
This antibody recognizes an epitope within the non?functional, middle domain of full?length Factor VIII.

Format

Supplied as
Purified IgG ? liquid
Approximate Protein Concentration
IgG concentration 1.0 mg/ml
Buffer Solution
Phosphate buffered saline

Preparation

Immunogen
Affinity purified human Factor VIII
Preservative Stabilizers
0.09% Sodium Azide (NaN3)

Storage/Stability

Store at +4°C or at ?20°C if preferred.
Storage in frost?free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody.  
Should this product contain a precipitate we recommend microcentrifugation before use.

Shelf Life
18 months from date of dispatch

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.