Protein Name & Synonyms:
ELISA, Immunohistology - Paraffin, Western Blotting
This product recognizes human follistatin isoform 288 (FS288).
Follistatin (FST) is a single-chain glycosylated protein of gonadal origin, originally identified as an antagonist of activin and suppressor of follicle stimulating hormone (FSH) synthesis/secretion. Alternative splicing of FST mRNA generates the two isoforms FS315 and FS288, the latter of which is the main cell-surface form and binds with high affinity to surface heparan sulfate proteoglycans, whilst FS315 binds with only low-affinity, and is considered to be the main circulating form of follistatin.
As well as activin, FST interacts with other growth factors such as bone morphogenetic proteins (BMPs) -2, -4 and -7, myostatin, and growth differentiation factor 9 (GDF-9), playing a key role in cellular differentiation/proliferation, embryonic development and tissue repair.
This product has been shown to exhibit 10% cross-reactivity with FS315 in an immunoassay.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Recombinant human FS288
0.09% Sodium Azide (NaN3)
Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.