Mouse Anti-Human Glycophorin-A (GYPA)

Mouse Anti Human Monoclonal Antibody (1 mg)

128-10065-2
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Antigen Information

Protein Name & Synonyms:
Glycophorin A

Antibody Specifications

Applications:
Western Blot, imunohistochemistry, flow cytometry. For WB use 1ug/ml of antibody. For flow cytometry use 5-10 ul per one million cells.
Concentration:
1mg/ml in PBS (after reconstitution)
Host Species:
Mouse
Reconstitution:
Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Synonyms

Glycophorin-A, MN sialoglycoprotein, PAS-2, Sialoglycoprotein alpha, CD235a, GYPA, GPA, MN, MNS, GPSAT, GPErik, HGpMiV, HGpMiXI, HGpSta(C).

Introduction

Glycophorins A & B (GYPA &GYPB) are the main sialoglycoproteins of the human erythrocyte membrane which carry the antigenic determinants for the MN and Ss blood groups. Along with the M or N and S or s antigens which normally occur in all populations, approximately 40 related variant phenotypes were identified. These variants comprise all the variants of the Miltenberger complex and some isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. GYPA is significant for the function of SLC4A1 and is necessary for high activity of SLC4A1. GYPA is involved in translocation of SLC4A1 to the plasma membrane. GYPA is also a receptor for: the influenza virus, Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans and is also a receptor for Hepatitis A virus (HAV).

Source

Immunogen
Recombinant Human GlycophorinA
Ig Subclass
Mouse IgG1
Purification Method
Protein A column

Formulation/Preparation

Protein Concentration
1mg/ml in PBS (after reconstitution)
Titer
By direct ELISA, 1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories).

Storage

Storage
In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
Shipping Conditions
Antibody is shipped lyophilized at ambient temperature.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.