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Antigen Information
Accession Number:
- P01233
Gene ID:
- 1082
Gene Symbols:
- CGB3
Protein Name & Synonyms:
hCG Beta
Target Species:
- Human
Antibody Specifications
Concentration:
IgG concentration 1.0 mg/ml
Description
Mouse Anti-hCG Beta (Free Specific)
Alternate Names / IDs
Synonyms
CGB3
Entrez Gene ID
1082
Specificity
This antibody specifically recognizes the beta subunit of human chorionic gonadotropin (hCG).
Minimal crossreactivity (0.5%) has been observed with the intact hCG molecule and negligible reactivity has been shown with the human luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroidstimulating hormone (TSH).
Human chorionic gonadotropin exists in 5 different variants (hCG, sulfated hCG, hyperglycosylated hCG, free beta hCG and hyperglycosylated free beta) that share the same amino acid sequence but have different functions (Cole 2012). hCG is a glycoprotein of 237 amino acids. Regular hCG has a molecular weight of 36,000 where oligosaccharides account for 25-30% of the MW (Cole 2010). It is composed of a 92 amino acid alpha subunit, common to the LH, FSH and TSH hormones, and of a unique beta subunit, which is recognized by this antibody.
Production of progesterone is not the only role of hCG: it also has numerous other functions, during pregnancy and as a marker for certain cancers (Cole LA 2012, 2010 and 2009).
Minimal crossreactivity (0.5%) has been observed with the intact hCG molecule and negligible reactivity has been shown with the human luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroidstimulating hormone (TSH).
Human chorionic gonadotropin exists in 5 different variants (hCG, sulfated hCG, hyperglycosylated hCG, free beta hCG and hyperglycosylated free beta) that share the same amino acid sequence but have different functions (Cole 2012). hCG is a glycoprotein of 237 amino acids. Regular hCG has a molecular weight of 36,000 where oligosaccharides account for 25-30% of the MW (Cole 2010). It is composed of a 92 amino acid alpha subunit, common to the LH, FSH and TSH hormones, and of a unique beta subunit, which is recognized by this antibody.
Production of progesterone is not the only role of hCG: it also has numerous other functions, during pregnancy and as a marker for certain cancers (Cole LA 2012, 2010 and 2009).
Format
Supplied as:
Purified IgG - liquid
Formulation
Phosphate buffered saline
Fusion Partners
Spleen cells from immunized BALB/c mice were fused with cells of the P3X63-Ag 8.653 myeloma cell line
Preservative
0.09% Sodium Azide (NaN3)
Immunogen
Chorionic Gonadotropin Beta subunit
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Shelf Life
18 months from date of despatch.
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
