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Mouse Anti-Human Heparanase-1

Mouse Anti-Human Heparanase-1

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DS-MB-03302
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Antigen Information

Protein Name & Synonyms:
Heparanase-1
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
IgG concentration 4.0 mg/ml
Purity:
98% by SDS PAGE
Species Reactivity:
Human, Mouse

This product detects bands of approximately 50kDa (corresponding to the subunit containing the active site) and 65kDa (the precursor of heparanase-1) when purified recombinant human heparanase samples are used.

Specificity

This product is specific to Heparanase-1, also know as HPA1, an endo-beta-D-glucuronidase that degrades heparan sulfate proteoglycans (HSPGs) in the extracellular matrix through cleavage of the heparan sulfate side chains.

Heparanase-1 is a heterodimer that is produced as a 65kDa latent precursor, consisting of an 8kDa subunit, a 50kDa subunit and a linker peptide. Activation of Heparanase-1 occurs through cleavage of the linker peptide, releasing the 8kDa subunit from the active 50kDa subunit.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Purity:
98% by SDS PAGE
Format Type:
Purified

Preparation

Immunogen:
Polypeptide from the 50 kDa subunit of heparanase
Preservative:
0.01% Thiomersal

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.