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770-729-2992
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Product Specifications
Size:
0.1 mg
Protein Information
Protein Name & Synonyms:
IRF5
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: 1/1000, 1/2000), Immunoprecipitation, Immunohistology - Paraffin, Western Blotting
Concentration (lot specific):
IgG concentration 1.0mg/ml
Species Reactivity:
Human
This product detects a band of approximately 58kDa in THP-1 cell lysates.
Specificity
This product recognizes human interferon regulatory factor 5 (IRF5), a 58kDa member of the IRF family which acts as a key regulator of interferon gene transcription, and is expressed in B cells and dendritic cells, and is inducible by type I interferon (IFN) in most lymphoid cells.
The role of IRF3 and IRF7 as transcriptional mediators of virus- and IFN-induced signaling pathways is well documented. Studies have shown that IRF5 can also regulate IFN gene transcription, but appears to be more restricted in its cellular expression and range of viral stimuli, and has the ability to induce a wide range of chemokines involved in T-lymphocyte recruitment, including RANTES, MCP-1 and IP-10.
The role of IRF3 and IRF7 as transcriptional mediators of virus- and IFN-induced signaling pathways is well documented. Studies have shown that IRF5 can also regulate IFN gene transcription, but appears to be more restricted in its cellular expression and range of viral stimuli, and has the ability to induce a wide range of chemokines involved in T-lymphocyte recruitment, including RANTES, MCP-1 and IP-10.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Immunogen:
Histidine-tagged recombinant peptide corresponding to amino acids 176-240 of human IRF5, purified from E. coli.
Preservative:
0.1% Sodium Azide (NaN3)
This product
Spleen cells from immunised Balb/c mice were fused with cells of the mouse Sp2/0 myeloma cell line.
Expiration:
12 months from the date of shipment when stored properly.
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
