Mouse Anti-Human LYN

Mouse Anti-Human LYN
CODE:  DS-MB-01810

Antigen Information

Protein Name & Synonyms:
LYN
Target Species:
  • Human

Antibody Specifications

Applications:
Immunofluorescence, Immunoprecipitation, Western Blotting
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Human, mouse and rat

This product detects a band of approximately 53-56kDa in human peripheral blood monocytes.

Specificity

This product recognizes p56/p53lyn (lyn), a 56kDa member of the src family of non-receptor protein tyrosine kinases (PTKs), predominantly expressed in tissues of hematopoietic origin.

The interaction between lyn and syk, is crucial for regulating the response of both mast cells and basophils, following Fc epsilon R1 receptor aggregation and activation. Once activated, the rapid tyrosine phosphorylation of ITAMs by lyn, serves as a binding site for the recruitment and activation of syk, triggering the phosphorylation of further adaptor and signaling molecules further down a complex signaling cascade.

This chain of events involving receptor aggregation, activation and tyrosine phosphorylation of ITAMs, is also vital for the survival and differentiation of B cells through the interaction of lyn and syk with the B cell receptor (BCR).

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Recombinant fragment of human Lyn (amino acids 8-238)
Preservative:
0.09%Sodium Azide