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Protein Information
Protein Name & Synonyms:
MAdCAM-1
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: 1/10 , 1/100), Flow Cytometry, Functional Assays, Immunohistology - Paraffin, Western Blotting
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Human
This product detects a band of approximately 60kDa.
Immunohistology:
This product does not require protein digestion pre-treatment of paraffin embedded sections prior to staining. This product does not require antigen retrieval prior to staining of paraffin sections.
Specificity
This product recognizes human mucosal addressin cell adhesion molecule 1 (MAdCAM-1), a 60kD cell surface protein that is involved in lymphocyte trafficking. MAdCAM-1 is expressed on high endothelial venules of Peyer's patches and mesenteric lymph nodes. MAdCAM-1 expression has also been reported in the gut lamina propria but This antibody reacts with the ligand-binding first Ig domain and reports suggest that a splice variant exists in the gut which is not recognized by This product This product is reported to block the interaction of MAdCAM-1 with alpha 4 beta 7, see Leung, E. et al. for details.
Storage/Stability
Store at -20 °C.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Low Endotoxin
Preparation
Immunogen:
Recombinant soluble MAdCAM-1-fc fusion protein
Preservative:
None present
This product
Spleen cells from immunised Balb/c mice were fused with cells of the mouse P3X63Ag8.653 myeloma cell line.
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
