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Antigen Information
Protein Name & Synonyms:
MALT1
Target Species:
- Human
Antibody Specifications
Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
1.0 mg/ml
Host Species:
Mouse
Species Reactivity:
Human
This product detects a band of approximately 93kDa.
Specificity
This product recognizes human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1), a 93kD paracaspase which has been reported to demonstrate proteolytic activity. In normal lymphocytes, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation. In T-cells, MALT1 is recruited by activated CARMA1, along with Bcl-10, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB.
MALT1 was initially identified as a recurrent translocation t(11;18)(q21:q21) in mucosal-associated lymphomas, which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2. Studies suggest that overexpression of MALT1, or expression of the API2-MALT1 fusion protein, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent.
This product is reported to recognize both MALT1 and the MALT1-API2 fusion protein.
MALT1 was initially identified as a recurrent translocation t(11;18)(q21:q21) in mucosal-associated lymphomas, which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2. Studies suggest that overexpression of MALT1, or expression of the API2-MALT1 fusion protein, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent.
This product is reported to recognize both MALT1 and the MALT1-API2 fusion protein.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Immunogen:
Recombinant protein corresponding to amino acids 701-808 located within the C-terminal of MALT1.
Preservative:
0.09% Sodium Azide (NaN3)
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
