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Mouse Anti-Human MDM2

Mouse Anti-Human MDM2

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DS-MB-01877
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Antigen Information

Protein Name & Synonyms:
MDM2
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, Immunoprecipitation, Immunohistology - Paraffin, Immunohistology - Resin
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Human, mouse

Specificity

This product recognizes the 90kD MDM2 protein, which forms a complex with p53 leading to p53 inhibition.

MDM2 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI.

MDM2 is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Synthetic peptide, CSRPSTSSRRRAISE, corresponding to amino acids 154-167 of human MDM2
Preservative:
0.09%Sodium Azide
This product
Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63Ag8.653 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.