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Antigen Information
Protein Name & Synonyms:
MDM2
Target Species:
- Human
Antibody Specifications
Applications:
Immunohistology - Frozen, Immunoprecipitation, Immunohistology - Paraffin, Immunohistology - Resin
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Human, mouse
Specificity
This product recognizes the 90kD MDM2 protein, which forms a complex with p53 leading to p53 inhibition.
MDM2 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI.
MDM2 is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer.
MDM2 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI.
MDM2 is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Immunogen:
Synthetic peptide, CSRPSTSSRRRAISE, corresponding to amino acids 154-167 of human MDM2
Preservative:
| 0.09% | Sodium Azide |
This product
Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63Ag8.653 myeloma cell line.
No posts found
Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
