Protein Name & Synonyms:
MICA + MICB
Immunohistology - Frozen, Flow Cytometry, Functional Assays, Immunoprecipitation
IgG concentration 1.0 mg/ml
This product is specific for nonclassical MHC class I chain A (MICA) and nonclassical MHC class I chain MICB (MICB).
MICA and MICB are stress inducible antigens, which are closely related and appear functionally indistinguishable. MICA and MICB are ligands for NKG2D, an activating receptor on most natural killer (NK) cells, CD8 T cells and gamma delta T cells.
MICA is principally expressed on intestinal epithelium, and several epithelial tumours. Expression may be induced to high surface levels by heat shock, oxidative stress, and virus infection.
This product is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells, see Jinushi, M. et al. for details.
Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Quality Control (Contaminants):
MICA transfected C1R cells
Spleen cells from immunised RBF/DnJ mice were fused with cells of the P3 mouse myeloma cell line.