Mouse Anti-Human MMP1

Mouse Anti-Human MMP1

$347.00
129-10455
+

Antigen Information

Protein Name & Synonyms:
MMP1
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
1.0mg/ml
Host Species:
Mouse
Species Reactivity:
Human

This product detects a band of approximately 37kDa

Specificity

This product recognizes human matrix metalloproteinase 1 (MMP-1). The MMP's are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMP's are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma. It is overexpressed in invasive melanoma, colorectal and esophageal cancers. It has also been implicated in arthritis and might influence atherosclerotic lesion formation. It might also be involved in the repair processes of the heart after myocardial infarction.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Ovalbumin conjugated synthetic peptide corresponding to a region within the C-terminus of human MMP-1.
Preservative:
0.09% Sodium Azide (NaN3)
This product
Spleen cells from immunised Balb/c mice were fused with cells of the Ag8563 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.