Mouse Anti-Human MMP3

This product recognizes human matrix metalloproteinase 3 (MMP-3 or stromelysin-1). The MMP's are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMP's are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-3 can degrade proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen. It can activate other MMP's and may be involved in the repair processes of the heart after myocardial infarction.