Mouse Anti-Human MMP3

Mouse Anti-Human MMP3

129-10458
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Antigen Information

Protein Name & Synonyms:
MMP3
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA, Immunohistology - Paraffin, Western Blotting
Concentration:
1.0mg/ml
Host Species:
Mouse
Species Reactivity:
Human

This product detects a band of approximately 50kDa in cell lysates.

Specificity

This product recognizes human matrix metalloproteinase 3 (MMP-3 or stromelysin-1). The MMP's are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMP's are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-3 can degrade proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen. It can activate other MMP's and may be involved in the repair processes of the heart after myocardial infarction.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Ovalbumin conjugated synthetic peptide corresponding to a region within the C-terminus of human MMP-3.
Preservative:
0.09% Sodium Azide (NaN3)
This product
Spleen cells from immunised Balb/c mice were fused with cells of the Ag8563 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.