Mouse Anti-Human PDGF R alpha / CD140a

Mouse Anti-Human PDGF R alpha / CD140a

$347.00
DS-MB-02106
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Antigen Information

Protein Name & Synonyms:
PDGF R alpha / CD140a
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 1 ug/ml, 2 ug/ml), Immunohistology - Paraffin, Western Blotting
Concentration:
1.0 mg/ml
Species Reactivity:
Human

Specificity

This product is specific for PDGF receptor alpha.
The ND50 was determined as 0.2-0.6 µg/ml for blocking 10 ng/ml of PDGF-AA biological activity on a quiescent confluent cell culture of human WS1 cells.

PDGF is a major serum mitogen that can exist as a homo- or heterodimeric protein consisting of disulphide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cellsurface PDGF receptors with different affinities. Whereas PDGF receptor alpha binds all three isoforms with high affinity, PDGF R beta binds PDGF-BB and AB but not PDGF-AA. Both PDGF receptor alpha and beta are members of the class III subfamily of receptor tyrosine kinases.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Purified recombinant human platelet-derived growth factor (PDGF) receptor alpha (extracellular domain), derived from the insect cell line Sf21.
Preservative:
0.09%Sodium Azide (NaN3)
1.5%Trehalose

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.