Mouse Anti-Human S100

This product recognizes S100 protein derived from human brain tissue. It is a 21kDa acidic calcium-binding protein synthesised by astroglial cells. It can be found predominantly as two isoforms, the alpha-beta heterodimer (S100a) and the beta-beta homodimer (S100b). The S100 family of proteins have been implicated in a large variety of intracellular and extracellular regulatory activities, such as cellular energy metabolism, cytoskeleton modification, cell proliferation and differentiation.

When glial cells are damaged, S100 protein is leaked into the extracellular matrix and cerebrospinal fluid, further releasing into the bloodstream. S100 protein can be used as a sensitive and reliable marker for nervous system damage, such as after brain damage or acute stroke.

This product recognizes both S100a (alpha-beta) and S100b (beta-beta).

This product is sensitive to EDTA and other bivalent-binding agents. Improved performance can be obtained in the presence of 5mM CaCl₂ in assay buffers.