Mouse Anti-Human SC5b-9

Mouse Anti-Human SC5b-9

$711.00
DS-MB-03410
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Antigen Information

Protein Name & Synonyms:
SC5b-9
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, ELISA, Flow Cytometry, Western Blotting
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Human

Specificity

This product recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kDa C5b which is bound to cells via 71 kDa C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kDa S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation.


This product has been reprted to work in western blotting applications.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Borate buffered saline
Format Type:
Purified

Preparation

Preservative:
0.1% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.