Mouse Anti-Human SLP-76

Mouse Anti-Human SLP-76

DS-MB-03547
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Antigen Information

Protein Name & Synonyms:
SLP-76
Target Species:
  • Human

Antibody Specifications

Applications:
Immunoprecipitation, Western Blotting
Concentration:
Ig concentration 1.0 mg/ml
Species Reactivity:
Human, Mouse, Porcine

This product detects a band of approximately 76kDa in T lymphocyte cell lysates.

Specificity

This product recognizes the SH2 domain-containing leucocyte protein (SLP-76), a 76kDa tyrosine phosphoprotein, expressed primarily by T lymphocytes and cells of the myeloid lineage.

SLP-76 is one of several adaptor proteins assisting with TCR-mediated signal transduction, through GRB2 binding, functioning as a substrate for the protein-tyrosine kinase ZAP-70 and thus playing a crucial role in both T cell ontogeny and activation. Other molecules that associate with SLP-76 include phospholipase C (PLC)❏❏gamma, Vav, Nck and fyn binding protein.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
A fusion protein corresponding to amino acids 216-434 of human SLP-76
Preservative:
0.09%Sodium Azide

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.