Protein Name & Synonyms:
ELISA (dilution: 1/100 , 1/500), Western Blotting
Ig concentration 1.0 mg/ml
This product detects a band of approximately 30kDa in Hela cell lysates.
This product recognizes suppressor of cytokine signaling 3 (SOCS-3), a 30kDa member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways.
SOCS-3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. The expression of SOCS-3 is inducible by numerous factors, including IL-6, IL-10, Toll-like receptor (TLR) agonists and IFN gamma, making this protein the focus of research into inflammatory diseases, such as Arthritis, Colitis, and Crohn's Disease. SOCS-3 expression has also been shown to affect IFN alpha sensitivity in tumour studies.
Recent studies in mice, have shown Notch signaling plays a critical role in the determination of M1 versus M2 macrophage polarization, and that RBPJ❏❏mediated Notch signaling, regulates this polarization through SOCS-3.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Full - length SOCS3 protein.