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Antigen Information
Protein Name & Synonyms:
SOS1
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: , 1.0ug/ml), Immunofluorescence, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Species Reactivity:
Human, Mouse
This product detects a band of approximately 150kDa in K562 and RAJI human cell lysates under reducing conditions.
Specificity
This product specifically recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 150kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases.
Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.
Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Immunogen:
Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1.
Preservative:
0.09% Sodium Azide (NaN3)
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
