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Antigen Information
Protein Name & Synonyms:
SYK
Target Species:
- Human
Antibody Specifications
Applications:
Immunoprecipitation, Western Blotting
Concentration:
Ig concentration 1.0 mg/ml
Species Reactivity:
Human, mouse and rat
This product detects a band of approximately 72kDa in Ramos & RBL cell lysates.
Specificity
This product recognizes protein tyrosine kinase p72syk (syk), a 72kDa non-receptor tyrosine kinase, critical for immunoreceptor signaling in hematopoietic cells, but also expressed by nonhematopoietic cells, including fibroblasts, endothelial cells and hepatocytes.
Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways.
Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and hematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.
Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways.
Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and hematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Immunogen:
Recombinant fragment corresponding to amino acids 5 - 360 of human syk.
Preservative:
| 0.09% | Sodium Azide |
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
