Mouse Anti-Bovine Rhodopsin

Mouse Anti-Bovine Rhodopsin

$733.00
129-10588
+

Antigen Information

Protein Name & Synonyms:
Rhodopsin
Target Species:
  • Bovine (cow)

Antibody Specifications

Applications:
Immunoprecipitation, Immunohistology - Paraffin, Western Blotting
Host Species:
Mouse
Species Reactivity:
Bovine, Amphibia, Mammals

Specificity

This product recognizes the sequence TETSQVAPA corresponding to aa 340 to 348 of bovine rhodopsin, a pigment of the retina responsible for the formation of photoreceptor cells and the first events in the perception of light. Rhodopsin consists of the protein opsin and a reversibly bound cofactor, retinal, a photoreactive chromophore. Upon light absorption the 11-cis-retinal is isomerised to all-trans retinal, leading to a change in the shape of rhodopsin. The change activates the associated G protein and triggers a second messenger cascade, eventually resulting in the transmission of a nerve impulse to the brain. The trans-retinal is released and converted back into 11-cis-retinal for re-entry into the cycle.

Defects in the gene cause various retinopathies such as retinitis pigmentosa and X-linked congenital stationary night blindness.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
10mM HEPES pH7.5, 150mM NaCl
Format Type:
Purified

Preparation

Immunogen:
Bovine rhodopsin
Preservative:
0.09% Sodium Azide (NaN3)
0.01% Bovine Serum Albumin
50% Glycerol

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.