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Protein Information
Protein Name & Synonyms:
Tacrolimus (FK-506)
Target Species:
- Chemical
Antibody Specifications
Applications:
ELISA
Concentration:
Ig concentration 1.0mg/ml
Species Reactivity:
Chemical
Specificity
This product detects FK-506, a macrolide with similar but more potent immunosuppressant activity than cyclosporine. It is a 23-membered lactone produced by the bacteria Streptomyces tsukubaensis.
FK-506 inhibits signal transduction and interleukin-2 transcription in CD4+ T helper lymphocytes, and is mainly used after allogenic organ transplantation to reduce organ rejection. Side effects of FK-506 treatment include nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension.
FK-506 inhibits signal transduction and interleukin-2 transcription in CD4+ T helper lymphocytes, and is mainly used after allogenic organ transplantation to reduce organ rejection. Side effects of FK-506 treatment include nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgM - liquid
Formulation:
TRIS buffered saline
Format Type:
Purified
Preparation
Immunogen:
FK-506-BSA conjugate
Preservative:
| 0.09% | Sodium Azide (NaN3) |
This product
Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
