Mouse Anti-TIF1 gamma / TRIM33

Mouse Anti-TIF1 gamma / TRIM33 Antibody, 100 µl

$420.00  
102-26442
+

Antigen Information

Accession Number:
  • Q9UPN9
Gene ID:
  • 51592
Gene Symbols:
  • TRIM33
Protein Name & Synonyms:
8030451N04Rik;AI413936;cb1085;DKFZp586K1123;E3 ubiquitin-protein ligase TRIM33;EC 6.3.2.-;Ectodermin;Ectodermin homolog;FLJ11429;FLJ32925;id:ibd2175;MGC136680;mKIAA11

Antibody Specifications

Applications:
WB
Host Species:
Mouse
Species Reactivity:
H
Clonality:
Monoclonal

Introduction

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).

Other Information

Antigen Type
Recombinant Protein

Images

WB (1:1000)

Western blot detection of TIF1 gamma / TRIM33 in MCF7 and HelaNE cell lysates using TIF1 gamma / TRIM33 mouse mAb (1:1000 diluted).Predicted band size: 120KDa.Observed band size: 140KDa.

WB

Storage/Stability

2-8°C (short-term); -20°C (long-term)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.