Rabbit Anti-Human MyoGEF (N-term)

Rabbit Anti-Human MyoGEF (N-term) Antibody, 400 ul

$408.00  
102-17017
+

Antigen Information

Accession Number:
  • Q3KR16
Gene ID:
  • 55200
Gene Symbols:
  • PLEKHG6
Protein Name & Synonyms:
MyoGEF (N-term)
Target Species:
  • Human

Antibody Specifications

Concentration:
0.5 mg/ml
Preparation:
This MyoGEF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-87 amino acids from the N-terminal region of human MyoGEF.
Species Reactivity:
Human
Clonality:
Polyclonal

Introduction

Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It Also activates RHOG and does not activate RAC1, or to a much lower extent than RHOA and RHOG. Its part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, It is required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, it is required for normal macropinocytosis.

Specificity

Other Names
PLEKHG6; Pleckstrin homology domain-containing family G member 6; Myosin-interacting guanine nucleotide exchange factor
NCBI Accession #
NP_001138328.1;NP_001138329.1;NP_060643.2

Format

Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
88960
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100; FC: 1:10-50
Western blot analysis of MyoGEF Antibody (N-term) (Cat# 102-17017) in NCI-H460 cell line lysates (35ug/lane). MyoGEF (arrow) was detected using the purified Pab.
Formalin-fixed and paraffin-embedded human lung carcinoma with MyoGEF Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Flow cytometric analysis of NCI-H292 cells using MyoGEF Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.