NRP1 is a transmembrane receptor that is involved in numerous biological processes, including angiogenesis, vascular permeability, axon guidance, and mitochondrial iron transport. In October 2020, NRP1 was first demonstrated to facilitate SARS-CoV-2 entry (J. L. Daly et al., Science 10.1126/science.abd3072 (2020)). After the SARS-CoV-2 Spike protein binds to the endogenous ACE2 receptor, the Spike protein is cleaved into two polypeptides: S1 and S2. The C-end rule motif on the S1 polypeptide binds to NRP1. Inhibition of this interaction reduces viral entry.