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Binding Assays

RayBiotech offers binding assays for studying receptor-ligand or drug-target interactions. Using an ELISA-like format, the protein or small molecule of interest is coated on a 96-well microplate and potential inhibitors are then added in the presence of the interacting molecule. This assay enables rapid, high throughput, in-vitro screening of potential inhibitors. Browse ready-made kits to query Spike-receptor interactions that facilitate SARS-CoV-2 viral entry into host cells, as well as to detect drug antibodies (DA) and anti-drug antibodies (ADA).

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COVID-19 Spike-ACE2 Binding Assay Kit

The RayBio® COVID-19 Spike-ACE2 binding assay kit is a patented, rapid, simple, and sensitive method to characterize the binding affinity of the SARS-CoV-2 Spike (S) protein and the Angiotensin I Converting Enzyme 2 (ACE2) receptor complex in the presence of potential inhibitors.

Positive and negative controls for the Spike-ACE2 binding assays are available as an accessory item. Click here.

Gene Symbols: ACE2, RBD, S, S-RBD, SRBD Size: 1, 2, or 5 x 96-Well Strip Microplate Kit Species Detected: Human, SARS-CoV-2 
CoV-ACE2S2-1
$487.00  
 
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COVID-19 Spike-NRP1 Binding Assay Kit
The RayBio® COVID-19 Spike-NRP1 binding assay kit is a rapid, simple, and sensitive method to characterize the binding affinity of the SARS-CoV-2 Spike (S) protein and the Neuropilin-1 (NRP1) receptor complex in the presence of potential inhibitors.
Gene Symbols: NRP1, S1F Size: 1, 2, or 5 x 96-Well Strip Microplate Kit Species Detected: Human, SARS-CoV-2 
CoV-NRP1S1-1
$487.00  
 
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COVID-19 Spike-AXL Binding Assay Kit
The RayBio® COVID-19 Spike-AXL binding assay kit is a patented, rapid, simple, and sensitive method to characterize the binding affinity of the SARS-CoV-2 Spike (S) protein and the AXL receptor complex in the presence of potential inhibitors.
Gene Symbols: AXL, S, UFO Size: 1, 2, or 5 x 96-Well Strip Microplate Kit Species Detected: Human, SARS-CoV-2 
CoV-AXLS1-1
$487.00  
 
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COVID-19 Spike-CendR-NRP1 Binding Assay Kit
The RayBio® COVID-19 Spike-CendR-NRP1 binding assay kit is a rapid, simple, and sensitive method to characterize the binding affinity of the SARS-CoV-2 Spike (S) protein's CendR motif with the Neuropilin-1 (NRP1) receptor complex in the presence of potential inhibitors.
Gene Symbols: NRP1, S Size: 1, 2, or 5 x 96-Well Strip Microplate Kit Species Detected: Human, SARS-CoV-2 
CoV-CendR-NRP1-1
$487.00  
 
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COVID-19 Spike Variant-ACE2 Binding Assay Kit

The RayBio® COVID-19 Spike Variant-ACE2 binding assay kits are a rapid, simple, and sensitive method to characterize the binding affinity of the SARS-CoV-2 Spike (S) protein variants and the Angiotensin I Converting Enzyme 2 (ACE2) receptor complex in the presence of potential inhibitors.

Positive and negative controls for the Spike-ACE2 binding assays are available as an accessory item. Click here.

Gene Symbols: ACE2, RBD, S, S-RBD, SRBD Size: 1, 2, or 5 x 96-Well Strip Microplate Kit Species Detected: Human, SARS-CoV-2 
CoV-SM1ACE2-1
$510.00  
 
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Human TNF-alpha / TNF-R1 Binding Assay
The RayBio® TNFa/TNFR1 binding assay kit is a rapid, simple, and sensitive method to characterize the binding affinity between tumor necrosis factor alpha (TNFα) and its receptor (TNFR1) in the presence of potential inhibitors within 4 hours.
Gene Symbols: TNFA, TNFAR, TNFR1, TNFRSF1A, TNFSF2 Size: 1, 2, or 5 x 96-Well Strip Microplate Kit Species Detected: Human 
BAH-TNFR1-TNF-1
$698.00  
 
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Human IL-6 / IL-6RB (gp130) Binding Assay
The RayBiotech IL-6 / IL-6RB (gp130) binding assay kit is a rapid, simple, and sensitive method to characterize the binding affinity between interleukin 6 (IL-6) and its receptor (IL-6 receptor subunit beta) in the presence of potential inhibitors.
Gene Symbols: IL6, IL6ST Size: 1, 2, or 5 x 96-Well Strip Microplate Kit Species Detected: Human 
BAH-IL6ST-IL6-1
$698.00  
 
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Human IL-6 / IL-6RA (gp80) Binding Assay
The RayBiotech IL-6 / IL-6RA (gp80) binding assay kit is a rapid, simple, and sensitive method to characterize the binding affinity between interleukin 6 (IL-6) and its receptor (IL-6 receptor subunit alpha) in the presence of potential inhibitors.
Gene Symbols: IL6, IL6R Size: 1, 2, or 5 x 96-Well Strip Microplate Kit Species Detected: Human 
BAH-IL6RA-IL6-1
$698.00  
 
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COVID-19 Spike-ACE2 Binding Assay Kit Controls
Purified antibodies that either inhibit (positive control) or don't inhibit (negative control) the SARS-CoV-2 Spike-ACE2 interaction. These controls can be used with all RayBio® Spike-ACE2 Binding Assay Kits.
Size: 2 vials of purified antibodies in liquid solution, each with 10 µL at 0.1 mg/ml 
SACE2-Controls
$55.00  
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