Rabbit Anti-PTPH1 (Center)

Rabbit Anti-PTPH1 (Center) Antibody, 400 ul
CODE:  102-17866

Antigen Information

Accession Number:
  • P26045
Gene ID:
  • 5774
Gene Symbols:
  • PTPN3
Protein Name & Synonyms:
PTPH1 (Center)
Target Species:
  • Human
  • Mouse

Antibody Specifications

Concentration:
1.000 mg/ml
Preparation:
This PTPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-397 amino acids from the Central region of human PTPH1.
Species Reactivity:
Human, Mouse, Human, Mouse
Clonality:
Polyclonal

Introduction

Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ?it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.

Specificity

Other Names
PTPN3; PTPH1; Tyrosine-protein phosphatase non-receptor type 3; Protein-tyrosine phosphatase H1
NCBI Accession #
NP_001138840.1;NP_001138841.1;NP_001138842.1;NP_001138843.1;NP_002820.3
Other Accession #
A2ALK8

Format

Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
103990
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
The anti-PTPH1 Center Pab (Cat# 102-17866) is used in Western blot to detect PTPH1 in mouse brain tissue lysate.
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PTPH1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)