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Antigen Information
Protein Name & Synonyms:
FLIP gamma / delta
Target Species:
- Human
Antibody Specifications
Applications:
Immunohistology - Frozen, Western Blotting
Concentration:
1.0mg/ml
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
This product detects bands of approximately 35kDa and 25kDa in Jurkat cell lysates.
Specificity
This product recognizes the apoptosis related protein designated FLIP (FLICE inhibitory protein).
FLIP interacts with the adaptor protein FADD, and with Caspase-8 (FLICE) and Caspase-10 (FLICE2) to inhibit apoptosis induced by death receptors including CD95, DR3, TRAIL-R and TNFR1.
FLICE inhibitory proteins were initially identified in virus and human and were accordingly designated as v-FLIPs and c-FLIPs. Four spice variants of c-FLIP have been identified and are classified as FLIP alpha, beta, delta and gamma. This product recognizes human and murine delta and gamma variants but not the alpha or beta, variants.
FLIP is widely expressed in human tissues and a diverse range of cell lines.
FLIP interacts with the adaptor protein FADD, and with Caspase-8 (FLICE) and Caspase-10 (FLICE2) to inhibit apoptosis induced by death receptors including CD95, DR3, TRAIL-R and TNFR1.
FLICE inhibitory proteins were initially identified in virus and human and were accordingly designated as v-FLIPs and c-FLIPs. Four spice variants of c-FLIP have been identified and are classified as FLIP alpha, beta, delta and gamma. This product recognizes human and murine delta and gamma variants but not the alpha or beta, variants.
FLIP is widely expressed in human tissues and a diverse range of cell lines.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antiserum to human FLIP gamma/delta (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen:
A peptide corresponding to aa191 - 209 at the C-terminus of human FLIP delta/FLIPs form.
Preservative:
0.02% Sodium Azide (NaN3)
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
