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Antigen Information
Protein Name & Synonyms:
IFN-beta
Target Species:
- Chicken
Antibody Specifications
Applications:
Functional Assays, Immunoprecipitation, Western Blotting
Concentration:
IgG concentration 0.5 mg/ml
Preparation:
Antisera to chicken Interferon Beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography on protein G.
Species Reactivity:
Chicken
This product detects a band of approximately 20 kDa.
Specificity
This product recognizes chicken Interferon beta (chIFN-beta). Reports suggest that chIFN exhibits properties similar to mammalian IFN type I (IFNI).
Functional studies revealed the presence of two distantly related IFNI genes, designated as IFN alpha and IFN beta, found on chicken chromosome Z. The serological distinction between these two IFNs has been verified using neutralisation assays, and there is evidence that the antiviral activity of chIFN-beta is approximately ten-fold less compared to chIFN-alpha. This would suggest that chIFNbeta might have a different physiological role, though chIFN-beta is expressed strongly in virus-infected cells. This product does not cross react with IFN gamma.
This antiserum neutralizes chIFN-beta and can be used to discriminate IFN alpha and IFN beta bioactivities, see Schwarz, H.et al. for details.
Functional studies revealed the presence of two distantly related IFNI genes, designated as IFN alpha and IFN beta, found on chicken chromosome Z. The serological distinction between these two IFNs has been verified using neutralisation assays, and there is evidence that the antiviral activity of chIFN-beta is approximately ten-fold less compared to chIFN-alpha. This would suggest that chIFNbeta might have a different physiological role, though chIFN-beta is expressed strongly in virus-infected cells. This product does not cross react with IFN gamma.
This antiserum neutralizes chIFN-beta and can be used to discriminate IFN alpha and IFN beta bioactivities, see Schwarz, H.et al. for details.
Storage/Stability
Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Azide Free
Preparation
Antisera to chicken Interferon Beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography on protein G.
Immunogen:
Recombinant chicken Interferon Beta
Preservative:
None present.
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
