Rabbit Anti-Chicken IL-1 beta

Rabbit Anti-Chicken IL-1 beta

DS-PB-01075
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Antigen Information

Protein Name & Synonyms:
IL-1 beta
Target Species:
  • Chicken

Antibody Specifications

Applications:
ELISA, Functional Assays, Western Blotting
Concentration:
IgG concentration 0.5 mg/ml
Preparation:
Antisera to chicken Interleukin 1 Beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography on protein G
Species Reactivity:
Chicken

This product detects a band of approximately 29kDa in HD-11 cell lysates transfected with chIL-1.

Specificity

This product recognizes chicken Interleukin 1 beta (chIL-1beta), which shares homology with mammalian IL-1beta.

IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression.

Studies using chicken models have indicated physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica.

This product neutralizes chicken IL-1 beta (1-2).

Storage/Stability

Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Azide Free

Preparation

Antisera to chicken Interleukin 1 Beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography on protein G

Immunogen:
Recombinant chicken IL-1
Preservative:
None present

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.