Protein Name & Synonyms:
CRY2, HCRY2, PHLL2, cryptochrome-2
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene.
WB 1:500 - 1:2000; IF 1:50 - 1:200
Recombinant fusion protein containing a sequence corresponding to amino acids 455-614 of human CRY2 (NP_066940.2).
Store at -20°. Avoid freeze / thaw cycles.