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Rabbit Anti-CXCR4 Antibody

Rabbit Anti-CXCR4 Antibody, (100 ug)

$378.00  
168-10863
+

Antigen Information

Accession Number:
  • P61073
Protein Name & Synonyms:
CXCR4

Antibody Specifications

Applications:
Western blot analysis (0.5-4 ug/ml), immunoprecipitation, and immunocytochemistry. However, the optimal conditions should be determined individually. A 43 kDa band should be detected. HeLa cell lysate can be used as a positive control.
Concentration:
0.5 mg/ml
Host Species:
Rabbit

Synonyms

chemokine (C-X-C motif) receptor 4, CXC chemokine receptor 4, CXC chemokine receptor -4, CXC chemokine receptor

Description

Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The alpha-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.

Source

Immunogen
Synthetic peptide mapping to the N-terminus of human CXCR4
Purification
Affinity purified

Format

Physical Appearance
Colorless liquid
Formulation
100 µg (0.5 mg/ml) peptide affinity purified rabbit anti-CXCR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Specificity

C-X-C chemokine receptor type 4

Storage

-20 °C. The shelf life is 12 months.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.