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Rabbit anti-EP300 Antibody

EP300 pAb

$200.00  
144-62588-50
+

Antigen Information

Accession Number:
  • Q09472
Gene ID:
  • 2033
Gene Symbols:
  • EP300
Protein Name & Synonyms:
EP300, KAT3B, RSTS2, p300, E1A binding protein p300
Target Species:
  • Human

Antibody Specifications

Applications:
WB, IHC, IF
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugation/Tag:
Unconjugated
Host Species:
Rabbit
Purity:
Affinity purification
Species Reactivity:
Human, Mouse, Rat
Isotype:
IgG

Background

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Dilutions

WB 1:500 - 1:2000; IHC 1:50 - 1:200; IF 1:50 - 1:200

Format

Calculated MW
264kDa
Observed MW
280kDa

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human EP300 (NP_001420.2).

Modification

Unmodified

Storage

Store at -20°. Avoid freeze / thaw cycles.

Images

Western blot

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.