Protein Name & Synonyms:
EP300, KAT3B, RSTS2, p300, E1A binding protein p300
WB, IHC, IF
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Human, Mouse, Rat
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
WB 1:500 - 1:2000; IHC 1:50 - 1:200; IF 1:50 - 1:200
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human EP300 (NP_001420.2).
Store at -20°. Avoid freeze / thaw cycles.