Protein Name & Synonyms:
Western blot analysis (1-2 ug/ml). However, the optimal conditions should be determined individually. The antibody detects GSK-3 from human, mouse, &, rat origin, non cross-reactive with GSK-3ß,.
DKFZp686D0638, GSK-3alpha, Glycogen synthase kinase-3, GSK-3 alpha
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that has been implicated in the regulation of cell fate and in the Wnt signaling pathway. GSK-3 plays an important role in the PI3 kinase and Akt mediated cell survival pathways, and its activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3alpha and Ser9 of GSK-3beta. GSK-3 has also been implicated in alzheimer?s disease. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3.
Synthetic peptide from human GSK-3alpha
100 µg (0.2 mg/ml) affinity-purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
-20 °C. The shelf life is 12 months.