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Antigen Information
Protein Name & Synonyms:
ACE2
Target Species:
- Human
Antibody Specifications
Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
IgG concentration 1.0 mg/ml
Preparation:
Antisera to human ACE2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Species Reactivity:
Human
Specificity
This product is specific for human Angiotensin-converting enzyme 2 (ACE2). ACE2 is a carboxypeptidase which is expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system.
ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation.
A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein.
ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation.
A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antisera to human ACE2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen:
Synthetic peptide corresponding to a sequence within the amino terminus of human ACE2.
Preservative:
| 0.02% | Sodium Azide |
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
