Rabbit Anti-Human AID (C-term)

Rabbit Anti-Human AID (C-term)

DS-PB-02385
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Antigen Information

Protein Name & Synonyms:
AID
Target Species:
  • Human

Antibody Specifications

Applications:
Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to human AID (CT) were raised by repeated immunisation of rabbits with highly purified antigen.Purified IgG pepared by affinity chromatography.
Species Reactivity:
Human, Mouse

This product detects a band of approximately 24kDa in Ramos whole cell lysates.

Specificity

This antibody recognizes an epitope within the C-terminal region (CT) of Activation-induced cytidine deaminase (AID), a 24kDa homologue of the RNA-editing cytidine deaminase enzyme, APOBEC-1.

Although the molecular mechanisms by which AID acts remain unclear, a growing number of studies reveal a requirement for AID during somatic hypermutation (SHM) and class switch recombination (CSR). These genetic modification events take place within highly specialised B cell germinal centers, during the final maturation stages of B cells, giving rise to high-affinity antibodies which use CSR to switch from IgM to IgG, IgA or IgE isotypes.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to human AID (CT) were raised by repeated immunisation of rabbits with highly purified antigen.
Purified IgG pepared by affinity chromatography.

Immunogen:
A 14 amino acid peptide located near human AID carboxy-terminus.
Preservative:
0.02% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.