Rabbit Anti-Human Androgen Receptor

Rabbit Anti-Human Androgen Receptor

$420.00
DS-PB-00165
+

Antigen Information

Protein Name & Synonyms:
Androgen Receptor
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin
Concentration:
IgG concentration 5.0 mg/ml
Immunogen Sequence:
S-T-E-D-T-A-E-Y-S-P-F-K-G-G-Y-T-K
Species Reactivity:
Human
Immunohistology:
This product does not require protein digestion pre-treatment or antigen retrieval using heat treatment prior to staining of paraffin sections.

Specificity

This product is specific for Androgen Receptor (AR).

Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation.

Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Synthetic peptide corresponding to the amino acids 1242 - 1255 of the native molecule conjugated to Keyhole limpet Haemocyanin.
Preservative:
0.09% Sodium Azide (NaN3)
Amino Acid Sequence:
S-T-E-D-T-A-E-Y-S-P-F-K-G-G-Y-T-K

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.