Protein Name & Synonyms:
Immunohistology - Paraffin
IgG concentration 5.0 mg/ml
This product does not require protein digestion pre-treatment or antigen retrieval using heat treatment prior to staining of paraffin sections.
This product is specific for Androgen Receptor (AR).
Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation.
Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Synthetic peptide corresponding to the amino acids 1242 - 1255 of the native molecule conjugated to Keyhole limpet Haemocyanin.
0.09% Sodium Azide (NaN3)
Amino Acid Sequence: