Rabbit Anti-Human APP (KPI domain)

Rabbit Anti-Human APP (KPI domain)

$571.00
DS-PB-00159
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Antigen Information

Protein Name & Synonyms:
APP (KPI domain)
Target Species:
  • Human

Antibody Specifications

Applications:
Immunoprecipitation, Immunohistology - Paraffin, Western Blotting
Preparation:
Antisera to human APP were raised by repeated immunisations of rabbits with highly purified antigen.
Species Reactivity:
Human, monkey

This product detects a band of approximately 115kDa in NTera2/DI cell lysates.

Immunohistology:
This product requires antigen retrieval using heat treatment prior to staining of paraffin embedded sections. *0.05M Tris pH7.0, followed by reduction and alkylation is recommended.

Specificity

This product recognizes an epitope in the Kunitz protease inhibitor (KPI) domain of human amyloid precursor protein (APP).

Only the APP-751 and APP-770 isoforms contain a KPI domain, it being absent from the APP-695 isoform that is most abundant in neuronal tissue. However, there is evidence that suggests KPI containing isoforms may be important in the pathogenesis of Alzheimer disease.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Serum - liquid
Format Type:
Serum

Preparation

Antisera to human APP were raised by repeated immunisations of rabbits with highly purified antigen.

Immunogen:
Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP.
Preservative:
0.02%Sodium Azide

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.