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Rabbit Anti-Human ASK1 (C-term.)

Rabbit Anti-Human ASK1 (C-term.)

$400.00  
129-10039
+ −

Antigen Information

Protein Name & Synonyms:
ASK1
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, Western Blotting
Concentration:
0.5 mg/ml
Host Species:
Rabbit
Species Reactivity:
Human

This product detects a band of approximately 155kDa in SW1353 cell lysates.

Specificity

This product recognizes human ASK1 (Apoptosis signal-regulating kinase 1) a 155kDa protein belonging to the protein kinase superfamily.

ASK1 is a serine/threonine kinase, also known as MAP kinase kinase kinase (MAPKKK), and plays an important role in the apoptotic response to various stimuli including oxidative stress, cytokines (e.g. TNF) and endoplasmic reticulum stress. Akt in conjunction to Hsp90 phosphorylates ASK1 at Ser83 to inhibit ASK1 induced apoptosis.

ASK1 is widely expressed in a variety of human tissues including the heart and pancreas.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to human ASK1 (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Immunogen:
A peptide corresponding to amino acids near the carboxy terminus of human ASK1.
Preservative:
0.02% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.