Rabbit Anti-Human ASK1 (pSer83)

Rabbit Anti-Human ASK1 (pSer83)

$273.00
DS-PB-00197
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Antigen Information

Protein Name & Synonyms:
ASK1 (pSer83)
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 1/5,000, 1/1,000), Western Blotting
Concentration:
IgG concentration 2.0mg/ml
Preparation:
Antisera to ASK1 (pSER83) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
Species Reactivity:
Human

This product detects a band of approximately 155kDa in SW1353 cell lysates.

Specificity

This product detects Apoptosis Signal-regulating Kinase 1 (ASK1) phosphorylated at serine83. ASK1 is a serine/threonine kinase also known as MAP kinase kinase kinase (MAPKKK), and plays an important role in the apoptotic response to various stimuli including oxidative stress, cytokines (e.g. TNF) and endoplasmic reticulum stress. Akt in conjunction to Hsp90 phosphorylates ASK1 at Ser83 to inhibit ASK1 induced apoptosis.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to ASK1 (pSER83) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.

Immunogen:
KLH conjugated peptide corresponding to amino acids 76-87 of human ASK-1 protein.
Preservative:
0.01%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.