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Antigen Information
Protein Name & Synonyms:
CASP14
Target Species:
- Human
Antibody Specifications
Applications:
Western Blotting
Concentration:
IgG concentration 0.5mg/ml
Preparation:
Antisera to Caspase-14 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human, mouse and rat
This product detects a band of approximately 27kDa in Jurkat cell lysates.
Specificity
This product detects an epitope within the C-terminal (CT) region of human caspase-14; a 27kD cysteine protease which is activated by zymogen processing during cellular differentiation. It is highly expressed by keratinocytes and trophoblast cells of the placenta, with lower expression in the choroid plexus, the pigmented layer of the retina, and hair follicles.
Expression of the caspase-14 gene has recently been identified in epithelial tumours, including cervical and bladder carcinoma. The biological function of caspase-14 in tumour and normal tissue remains to be classified.
Expression of the caspase-14 gene has recently been identified in epithelial tumours, including cervical and bladder carcinoma. The biological function of caspase-14 in tumour and normal tissue remains to be classified.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antisera to Caspase-14 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen:
A 16 amino acid peptide from near the carboxy-terminus of human Caspase-14.
Preservative:
| 0.02% | Sodium Azide (NaN3) |
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
