Cart Is Empty
- Menu
-
Products
-
Research Topics
-
- Akt Signaling Pathway
- AMPK Signaling pathway
- ErbB/HER Signaling Pathway
- Hedgehog Signaling Pathway
- HIF1-alpha Signaling Pathway
- IGFR1 Signaling Pathway
- JAK-STAT Signaling Pathway
- MAPK Signaling Pathway
- mTOR Signaling Pathway
- NF-kappaB Signaling Pathway
- Notch Signaling Pathway
- p53 Signaling Pathway
- View more →
-
-
Services
-
Resources
- Contact Us
- ISO 13485:2016
Home/Search results/Products/Antibodies/Phosphorylation/Apoptosis/Signal Transduction/Regulation/Rabbit Anti-Human CASP2
Antigen Information
Protein Name & Synonyms:
CASP2
Target Species:
- Human
Antibody Specifications
Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antiserum to human caspase-2 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Species Reactivity:
Human, Mouse
Specificity
This product recognizes human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family.
Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis.
In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.
Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis.
In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antiserum to human caspase-2 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen:
Synthetic peptide corresponding to 6 amino acid sequence from the amino-terminus of human Caspase-2.
Preservative:
0.02% Sodium Azide (NaN3)
No posts found
Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
Account
Stay Connected
RayBiotech Life
3607 Parkway Lane Suite 200
Peachtree Corners, GA 30092
Tel: 770-729-2992, 1-888-494-8555
Fax: 770-206-2393
Email: info@raybiotech.com
