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Antigen Information
Protein Name & Synonyms:
CD167
Target Species:
- Human
Antibody Specifications
Applications:
Immunohistology - Paraffin
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to CD167 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human
Specificity
This product detects an epitope within the C-terminal of human CD167, a Discoidin Domain Receptor (DDR) also known as DDR1. CD167, a receptor for collagen, is widely expressed in normal and transformed epithelial cells, and may regulate cell adhesion, proliferation and extracellular matrix remodelling.
CD167 is a 125kD protein which is partially processed into a 62kD membrane-anchored beta-subunit and a 54kD soluble alpha-subunit. This process, also termed shedding, is significantly enhanced upon CD167 activation.
CD167 has been demonstrated to be a direct transcriptional target of the p53 tumour suppressor gene, and is significantly over-expressed in breast, ovarian, oesophageal, and paediatric brain tumours.
CD167 is a 125kD protein which is partially processed into a 62kD membrane-anchored beta-subunit and a 54kD soluble alpha-subunit. This process, also termed shedding, is significantly enhanced upon CD167 activation.
CD167 has been demonstrated to be a direct transcriptional target of the p53 tumour suppressor gene, and is significantly over-expressed in breast, ovarian, oesophageal, and paediatric brain tumours.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antisera to CD167 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen:
Synthetic peptide: C-terminal region of human CD167.
Preservative:
0.1% Sodium Azide (NaN3)
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
